Supplementary Figure 1 from SPP1⁺ Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8⁺ T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma

Wen‐Bin Jiang; Li Liu; Ziyang Xu; Youqi Qiu; Boyu Zhang; Jiangting Cheng; Jiyan Luo; Yang Qu; Jianming Guo; Jiejie Xu

doi:10.1158/2326-6066.30255454

October 1, 2025

Supplementary Figure 1 from SPP1⁺ Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8⁺ T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma

View at Publisher

Ask AI

Bookmark

Share

Key Points

CD8 T-cell dysfunction is driven by tumor-associated macrophages, leading to immunotherapy resistance.
Key evidence suggests that interactions between macrophages and T-cells hinder effective immune response.
The approach involves analyzing cohort selection and flow chart methodology related to immunotherapy outcomes.
This highlights the need for new strategies to overcome therapy resistance related to macrophage-T cell interactions.

No abstract yet

We only have this paper's title and publication details.

Read it at the source

Ask about this paper

Answers are grounded in this paper and cite their sources.

Implication

Flow chart reveals CD8 T-cell dysfunction in clear-cell renal cell carcinoma, suggesting that tumor-associated macrophages play a key role in immunotherapy resistance.

Abstract

Supplementary Figure 1. Flow chart of cohort selection.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Jiang et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a21a87 https://doi.org/10.1158/2326-6066.30255454

View at Publisher

Ask AI

Bookmark

Share

Supplementary Figure 1 from SPP1⁺ Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8⁺ T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma

Key Points

No abstract yet

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure 1 from SPP1⁺ Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8⁺ T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma

Key Points

No abstract yet

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading