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October 1, 2025

Supplementary Figure 18 from SPP1⁺ Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8⁺ T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma

Wenbin Jiang Li Liu Ziyang Xu Youqi Qiu Boyu Zhang Jiangting Cheng Jiyan Luo Yang Qu Jianming Guo Jiejie Xu

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Key Points

SPP1+ tumor-associated macrophages drive CD8 T-cell dysfunction, reducing immunotherapy effectiveness.
Following SPP1 blockade, key changes in the tumor microenvironment (TME) were observed, impacting T-cell activity.
Analysis of the TME revealed the role of macrophages in mediating immunotherapy resistance in clear-cell renal cell carcinoma.
Findings may inform new strategies for overcoming immunotherapy resistance in cancer treatment.

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Implication

Supplementary figure reveals SPP1 blockade alters TME, suggesting a role in immunotherapy resistance.

Abstract

Supplementary Figure 18. Changes in the TME following SPP1 blockade.

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Cite This Study

Jiang et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a21a17 https://doi.org/10.1158/2326-6066.30255427

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Synapse has enriched 8 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure 19 from SPP1<sup>+</sup> Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8<sup>+</sup> T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma2025
2Supplementary Figure 14 from SPP1<sup>+</sup> Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8<sup>+</sup> T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma2025
3Supplementary Figure 11 from SPP1<sup>+</sup> Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8<sup>+</sup> T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma2025
4Supplementary Figure 2 from SPP1<sup>+</sup> Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8<sup>+</sup> T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma2025
5Supplementary Figure 13 from SPP1<sup>+</sup> Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8<sup>+</sup> T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma2025
6Supplementary Figure 12 from SPP1<sup>+</sup> Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8<sup>+</sup> T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma2025
7Supplementary Figure 15 from SPP1<sup>+</sup> Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8<sup>+</sup> T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma2025
8Supplementary Figure 4 from SPP1<sup>+</sup> Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8<sup>+</sup> T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma2025