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October 2, 2025Open Access

Supplementary Figure 14 from SPP1+ Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8+ T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma

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Authors

WJWen‐Bin JiangLLLi LiuZXZiyang Xu

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Overview

Figure illustrates how tumor-associated macrophages lead to CD8 T-cell dysfunction, indicating a mechanism of immunotherapy resistance.

Key Points

  • Tumor-associated macrophages drive immunotherapy resistance by compromising CD8 T-cell function.
  • CyTOF characterization of T cells reveals changes linked to resistance in clear-cell renal cell carcinoma.
  • These findings highlight the role of tumor-associated macrophages in modulating T-cell responses.
  • Understanding these interactions may assist in developing new therapeutic strategies for clear-cell renal cell carcinoma.

Cite This Study

Jiang et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a21a9dhttps://doi.org/10.1158/2326-6066.30255439
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