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October 1, 2025Open Access

Supplementary Figure 14 from SPP1⁺ Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8⁺ T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma

Wenbin Jiang Li Liu Ziyang Xu Youqi Qiu Boyu Zhang Jiangting Cheng Jiyan Luo Yang Qu Jianming Guo Jiejie Xu

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Key Points

Tumor-associated macrophages drive immunotherapy resistance by compromising CD8 T-cell function.
CyTOF characterization of T cells reveals changes linked to resistance in clear-cell renal cell carcinoma.
These findings highlight the role of tumor-associated macrophages in modulating T-cell responses.
Understanding these interactions may assist in developing new therapeutic strategies for clear-cell renal cell carcinoma.

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Implication

Figure illustrates how tumor-associated macrophages lead to CD8 T-cell dysfunction, indicating a mechanism of immunotherapy resistance.

Abstract

Supplementary Figure 14. Characterization of T cells through CyTOF.

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Cite This Study

Jiang et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a21a9d https://doi.org/10.1158/2326-6066.30255439

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Keep reading

Synapse has enriched 8 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure 13 from SPP1<sup>+</sup> Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8<sup>+</sup> T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma2025
2Supplementary Figure 15 from SPP1<sup>+</sup> Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8<sup>+</sup> T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma2025
3Supplementary Figure 10 from SPP1<sup>+</sup> Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8<sup>+</sup> T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma2025
4Supplementary Figure 19 from SPP1<sup>+</sup> Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8<sup>+</sup> T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma2025
5Supplementary Figure 3 from SPP1<sup>+</sup> Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8<sup>+</sup> T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma2025
6Supplementary Figure 18 from SPP1<sup>+</sup> Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8<sup>+</sup> T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma2025
7Supplementary Figure 1 from SPP1<sup>+</sup> Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8<sup>+</sup> T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma2025
8Supplementary Figure 12 from SPP1<sup>+</sup> Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8<sup>+</sup> T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma2025