October 2, 2025Open Access

Supplementary Figure 3 from SPP1+ Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8+ T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma

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Authors

WJWenbin JiangDalian Medical University LLLi LiuBrigham and Women's Hospital ZXZiyang XuTianjin University

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Implication

This research characterizes tumor-associated macrophages and T cells in clear-cell renal cell carcinoma, suggesting new insights into immunotherapy resistance.

Key Points

Tumor-associated macrophages contribute to CD8 T-cell dysfunction, promoting immunotherapy resistance in clear-cell renal cell carcinoma.
Analysis showed distinct characteristics of TAMs and T cells using CyTOF and flow cytometry in ccRCC biopsies.
Assessment focused on the interaction between immune cells in the tumor microenvironment, highlighting potential therapeutic targets.
Results indicate that modifying TAM behavior may enhance the effectiveness of existing immunotherapy strategies.

Cite This Study

Jiang et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a21aa7 https://doi.org/10.1158/2326-6066.30255418

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Implication

This research characterizes tumor-associated macrophages and T cells in clear-cell renal cell carcinoma, suggesting new insights into immunotherapy resistance.

Supplementary Figure 3 from SPP1+ Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8+ T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma

Discussion

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Implication

Key Points

Cite This Study

Supplementary Figure 3 from SPP1+ Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8+ T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma

Discussion

Member takes

Implication

Key Points

Cite This Study

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