October 3, 2025Open Access

Supplementary Figure 16 from SPP1+ Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8+ T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma

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Discussion

Supplementary analysis shows SPP1+ TAMs increase CD8 T-cell dysfunction in renal cell carcinoma, suggesting immunotherapy resistance.

SPP1+ TAMs are linked to CD8 T-cell dysfunction in clear-cell renal cell carcinoma, impacting treatment outcomes.
The analysis demonstrates a significant correlation between SPP1+ TAMs infiltration and immune cell dynamics.
The assessment of immune cell infiltration focuses on how these interactions may contribute to immunotherapy resistance.
Understanding this relationship may provide insights for improved therapeutic strategies in renal cell carcinoma.

Jiang et al. (2025) studied this question.

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