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October 2, 2025

Supplementary Figure 7 from SPP1⁺ Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8⁺ T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma

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SPP1+ TAM infiltration significantly correlates with reduced overall survival in ccRCC patients.
Univariate Cox analysis indicates a relationship between SPP1+ TAMs and progression-free survival rates.
The findings highlight the critical link between macrophage infiltration and T-cell dysfunction in immunotherapy outcomes.
The results underscore the potential need for targeting TAMs to enhance immunotherapy responses.

Implication

Analysis demonstrates SPP1+ TAM infiltration correlates with poor OS and PFS in ccRCC patients, suggesting immunotherapy resistance links.

Abstract

Supplementary Figure 7. Univariate Cox analysis of the correlation between SPP1+ TAMs infiltration and OS/PFS among ccRCC patients treated with immunotherapy.

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Cite This Study

Jiang et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a21a0b https://doi.org/10.1158/2326-6066.30255406

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Implication

Analysis demonstrates SPP1+ TAM infiltration correlates with poor OS and PFS in ccRCC patients, suggesting immunotherapy resistance links.

Abstract

Supplementary Figure 7. Univariate Cox analysis of the correlation between SPP1+ TAMs infiltration and OS/PFS among ccRCC patients treated with immunotherapy.

Supplementary Figure 7 from SPP1⁺ Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8⁺ T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure 7 from SPP1⁺ Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8⁺ T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma

Key Points

Implication

Abstract

Discussion

Cite This Study

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