October 2, 2025Open Access

Supplementary Figure 6 from SPP1+ Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8+ T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma

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Discussion

Supplementary Figure reveals association of spp1+ TAMs with PFS in clear-cell renal cell carcinoma post-immunotherapy.

SPP1+ TAMs negatively impact progression-free survival after immunotherapy in clear-cell renal cell carcinoma.
The study demonstrates a significant association between TAM infiltration and CD8 T-cell dysfunction.
Clear-cell renal cell carcinoma patients with high TAM presence may experience worse immunotherapy outcomes.
Understanding TAMs role could lead to new strategies in managing immunotherapy resistance in ccRCC.

Jiang et al. (2025) studied this question.

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