October 2, 2025

Supplementary Figure 17 from SPP1⁺ Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8⁺ T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma

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SPP1+ tumor-associated macrophages are linked to CD8 T-cell dysfunction, driving resistance to immunotherapy.
Analysis reveals a correlation between SPP1+ infiltrating macrophages and BAP1 mutations in clear-cell renal cell carcinoma.
Observational analysis highlights crucial mechanisms of immunotherapy resistance in ccRCC, influenced by tumor microenvironment.
Understanding these interactions may enable novel strategies to improve patient outcomes in ccRCC treatment.

Implication

Supplementary analysis shows how SPP1+ TAMs correlate with BAP1 mutation, indicating potential therapeutic targets in ccRCC.

Supplementary Figure 17. SPP1+ TAMs infiltration correlates with BAP1 mutation in ccRCC.

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Jiang et al. (2025) studied this question.

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Supplementary analysis shows how SPP1+ TAMs correlate with BAP1 mutation, indicating potential therapeutic targets in ccRCC.

Supplementary Figure 17. SPP1+ TAMs infiltration correlates with BAP1 mutation in ccRCC.