October 2, 2025Open Access

Supplementary Figure 2 from SPP1+ Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8+ T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma

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Discussion

Supplementary data validates SPP1+ TAMs signature and its role in CD8+ T-cell dysfunction, suggesting implications for immunotherapy.

SPP1+ tumor-associated macrophages contribute to CD8+ T-cell dysfunction in clear-cell renal cell carcinoma.
The presence of SPP1+ TAMs is linked to resistance against immunotherapy, posing challenges for treatment outcomes.
Validation of the SPP1+ signature supports its significance as a target for enhancing immunotherapy efficacy.
Understanding TAMs' role is critical for developing strategies to overcome immune resistance mechanisms.

Jiang et al. (2025) studied this question.

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