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October 1, 2025Open Access

Supplementary Figure 19 from SPP1⁺ Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8⁺ T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma

Wenbin Jiang Li Liu Ziyang Xu Youqi Qiu Boyu Zhang Jiangting Cheng Jiyan Luo Yang Qu Jianming Guo Jiejie Xu

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Key Points

SPP1 blockade notably alters CD8+ T-cell function, potentially reversing immunotherapy resistance.
Key changes in CD8+ T cells were observed following SPP1 blockade, indicating its role in therapeutic responses.
The approach involved assessing T-cell dynamics in clear-cell renal cell carcinoma after specific macrophage targeting.
These findings highlight the important link between tumor-associated macrophages and T-cell dysfunction in cancer therapy.

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Implication

Observational analysis uncovers SPP1 blockade effects on CD8+ T-cell changes in renal cancer, suggesting new treatment pathways.

Abstract

Supplementary Figure 19. Changes in CD8+ T cells following SPP1 blockade.

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Cite This Study

Jiang et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a21a5e https://doi.org/10.1158/2326-6066.30255424

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Synapse has enriched 8 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure 18 from SPP1<sup>+</sup> Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8<sup>+</sup> T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma2025
2Supplementary Figure 15 from SPP1<sup>+</sup> Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8<sup>+</sup> T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma2025
3Supplementary Figure 14 from SPP1<sup>+</sup> Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8<sup>+</sup> T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma2025
4Supplementary Figure 11 from SPP1<sup>+</sup> Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8<sup>+</sup> T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma2025
5Supplementary Figure 13 from SPP1<sup>+</sup> Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8<sup>+</sup> T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma2025
6Supplementary Figure 12 from SPP1<sup>+</sup> Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8<sup>+</sup> T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma2025
7Supplementary Figure 2 from SPP1<sup>+</sup> Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8<sup>+</sup> T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma2025
8Supplementary Figure 4 from SPP1<sup>+</sup> Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8<sup>+</sup> T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma2025