Supplementary Figure 15 from SPP1⁺ Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8⁺ T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma

Wen‐Bin Jiang; Li Liu; Ziyang Xu; Youqi Qiu; Boyu Zhang; Jiangting Cheng; Jiyan Luo; Yang Qu; Jianming Guo; Jiejie Xu

doi:10.1158/2326-6066.30255436

October 1, 2025Open Access

Supplementary Figure 15 from SPP1⁺ Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8⁺ T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma

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Key Points

CD8+ T-cell dysfunction is linked to tumor-associated macrophages in clear-cell renal cell carcinoma, highlighting a key interaction.
Characterization of CD8+ T cells using flow cytometry demonstrates the impact of tumor-associated macrophages on immunotherapy outcomes.
The study employs flow cytometry to assess T-cell characteristics, providing critical insights into immunotherapy resistance mechanisms.
This work underscores the potential of targeting tumor-associated macrophages to improve immunotherapy efficacy in renal cell carcinoma.

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Implication

Observational analysis reveals CD8+ T-cell dysfunction in clear-cell renal cell carcinoma, suggesting tumor-associated macrophages drive immunotherapy resistance.

Abstract

Supplementary Figure 15. Characterization of CD8+ T cells through flow cytometry.

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Jiang et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a21aed https://doi.org/10.1158/2326-6066.30255436

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Supplementary Figure 15 from SPP1⁺ Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8⁺ T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma

Key Points

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Implication

Abstract

Discussion

Cite This Study

Supplementary Figure 15 from SPP1⁺ Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8⁺ T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma

Key Points

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Implication

Abstract

Discussion

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