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October 2, 2025Open Access

Supplementary Figure 15 from SPP1+ Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8+ T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma

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Authors

WJWen‐Bin JiangLLLi LiuZXZiyang Xu

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Overview

Observational analysis reveals CD8+ T-cell dysfunction in clear-cell renal cell carcinoma, suggesting tumor-associated macrophages drive immunotherapy resistance.

Key Points

  • CD8+ T-cell dysfunction is linked to tumor-associated macrophages in clear-cell renal cell carcinoma, highlighting a key interaction.
  • Characterization of CD8+ T cells using flow cytometry demonstrates the impact of tumor-associated macrophages on immunotherapy outcomes.
  • The study employs flow cytometry to assess T-cell characteristics, providing critical insights into immunotherapy resistance mechanisms.
  • This work underscores the potential of targeting tumor-associated macrophages to improve immunotherapy efficacy in renal cell carcinoma.

Cite This Study

Jiang et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a21aedhttps://doi.org/10.1158/2326-6066.30255436
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