What type of study is this?

This is a Quantitative Study study.

October 3, 2025Open Access

Supplementary Figure 5 from SPP1+ Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8+ T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma

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Univariate logistic regression shows correlation between spp1+ TAM infiltration and ORR in ccRCC patients, indicating treatment challenges.

Increased spp1+ TAM infiltration correlates with resistance to immunotherapy in ccRCC patients, affecting treatment outcomes.
The study reveals a significant association with objective response rate (ORR) among this population treated with immunotherapy.
Using univariate logistic regression analysis, the correlation between TAM infiltration and treatment effectiveness was assessed.
This finding highlights the role of TAMs in immunotherapy response, suggesting potential targets for enhancing treatment efficacy.

Jiang et al. (2025) studied this question.

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Univariate logistic regression shows correlation between spp1+ TAM infiltration and ORR in ccRCC patients, indicating treatment challenges.