What type of study is this?

This is a Cross-Sectional Study study.

October 2, 2025

Supplementary Figure 9 from SPP1+ Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8+ T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma

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Authors

WJWenbin JiangDalian Medical University LLLi LiuBrigham and Women's Hospital ZXZiyang XuTianjin University

Discussion

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Implication

Multivariate analysis shows correlation of SPP1+ TAMs with overall survival and recurrence-free survival in ccRCC patients, indicating significant prognostic implications.

Key Points

SPP1+ tumor-associated macrophages increase the risk of immunotherapy resistance in clear-cell renal cell carcinoma.
The analysis revealed a significant correlation between SPP1+ TAMs and overall survival in patients with ccRCC.
This study employed multivariate analysis to examine the relationship between TAMs infiltration and patient outcomes.
These findings support the potential targeting of SPP1+ TAMs for improved outcomes in immunotherapy.

Cite This Study

Jiang et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a21aa6 https://doi.org/10.1158/2326-6066.30255400

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Implication

Multivariate analysis shows correlation of SPP1+ TAMs with overall survival and recurrence-free survival in ccRCC patients, indicating significant prognostic implications.

Supplementary Figure 9 from SPP1+ Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8+ T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma

Discussion

Member takes

Implication

Key Points

Cite This Study

Supplementary Figure 9 from SPP1+ Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8+ T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma

Discussion

Member takes

Implication

Key Points

Cite This Study

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