Key points are not available for this paper at this time.
Reliable, quantitative assessment of fat and iron is important in the management of chronic liver diseases. Confounder-corrected chemical-shift-encoded (CSE)-MRI estimates proton-density fat-fraction (PDFF) and R2* as quantitative biomarkers for fat and iron, which have been shown to be highly reproducible across centers, field strengths and manufacturers. However, reproducibility in the setting of concomitantly high levels of fat and iron is poorly understood. To ensure the fidelity of CSE-MRI in clinical routine, a validation study was performed under controlled conditions on a phantom that modulates fat and iron simultaneously. Excellent multi-center and multi-vendor reproducibility of CSE-MRI PDFF and R2* was found.
Starekova et al. (Wed,) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: