Chemical shift-encoded MRI for proton-density fat-fraction quantification was accurate and reproducible across sites and vendors, with an overall absolute bias of 0.22% (95% CI 0.07%-0.38%).
Chemical shift-encoded MRI provides highly accurate and reproducible quantification of proton-density fat-fraction across different sites, vendors, and field strengths in a phantom model.
Effect estimate: Absolute bias 0.22% (95% CI 0.07%-0.38%)
Purpose To evaluate the accuracy and reproducibility of quantitative chemical shift-encoded (CSE) MRI to quantify proton-density fat-fraction (PDFF) in a fat–water phantom across sites, vendors, field strengths, and protocols. Methods Six sites (Philips, Siemens, and GE Healthcare) participated in this study. A phantom containing multiple vials with various oil/water suspensions (PDFF:0%–100%) was built, shipped to each site, and scanned at 1.5T and 3T using two CSE protocols per field strength. Confounder-corrected PDFF maps were reconstructed using a common algorithm. To assess accuracy, PDFF bias and linear regression with the known PDFF were calculated. To assess reproducibility, measurements were compared across sites, vendors, field strengths, and protocols using analysis of covariance (ANCOVA), Bland–Altman analysis, and the intraclass correlation coefficient (ICC). Results PDFF measurements revealed an overall absolute bias (across sites, field strengths, and protocols) of 0.22% (95% confidence interval, 0.07%–0.38%) and R2 > 0.995 relative to the known PDFF at each site, field strength, and protocol, with a slope between 0.96 and 1.02 and an intercept between −0.56% and 1.13%. ANCOVA did not reveal effects of field strength (P = 0.36) or protocol (P = 0.19). There was a significant effect of vendor (F = 25.13, P = 1.07 × 10−10) with a bias of −0.37% (Philips) and −1.22% (Siemens) relative to GE Healthcare. The overall ICC was 0.999. Conclusion CSE-based fat quantification is accurate and reproducible across sites, vendors, field strengths, and protocols. Magn Reson Med 77:1516–1524, 2017. © 2016 International Society for Magnetic Resonance in Medicine
Hernando et al. (Fri,) reported a other. Chemical shift-encoded (CSE) MRI was evaluated on Accuracy (PDFF bias) and reproducibility (Absolute bias 0.22%, 95% CI 0.07%-0.38%). Chemical shift-encoded MRI for proton-density fat-fraction quantification was accurate and reproducible across sites and vendors, with an overall absolute bias of 0.22% (95% CI 0.07%-0.38%).