Effectiveness of Urinary Cyanoethyl Mercapturic Acid (Cema) as Biomarkers for Acrylonitrile Exposure

Introduction. Acrylonitrile (AN) is a chemical compound that is used in the production of plastics, and resins. Tobacco smoke is the major non-occupational source for AN exposure. Exposure to AN can pose health risks including respiratory, and eye irritation, as well as potential carcinogenic effects. Methods. This study conducted a literature search using evidence-based database focusing on clinical questions using the “PICO” method, with following database: ‘’PubMed,’’ ‘’Embase,’’ ‘’Cochrane,’’ and ‘’google scholar.’’ The inclusion criteria are research in humans, English language, free full text, worker respondent, and diagnostic study. The exclusion criteria are review article, articles that do not use a CEMA measurements, and article more than 5 years. Results. CEMA can serve as chemically-specific biomarkers for AN exposure. Significant correlations between Cotinine and CEMA values, both before the work shift (rsp =0.473, p Discussion. Significant post-shift increases in CEMA concentrations for the high-exposure group indicated a proportional relationship with AN exposure. The research also revealed notable correlations between urinary cotinine levels, a nicotine metabolite, and CEMA values in the non-exposed group. Multiple linear regression analysis identified AN exposure, working shift, and urinary cotinine as key determinants of urinary CEMA concentrations. Conclusion. CEMA in urine can be considered as biomarker for biomonitoring of AN exposure. Cotinine and CEMA lies in their use as indicators of exposure to different toxicants present in cigarette smoke. The study has certain limitations, including potential biases. For example, the median age of each group.