Pd29-03 Association of Smoking With Concurrent and Long-Term Health-Related Quality of Life (Hrqol) Outcomes in Prostate Cancer Survivors

You have accessJournal of UrologyProstate Cancer: Epidemiology & Natural History I (PD29)1 May 2024PD29-03 ASSOCIATION OF SMOKING WITH CONCURRENT AND LONG-TERM HEALTH-RELATED QUALITY OF LIFE (HRQOL) OUTCOMES IN PROSTATE CANCER SURVIVORS Hannah Kay, Ram Sankar Basak, Deborah Usinger, Ronald Chen, Richard Matulewicz, Adam Goldstein, Kimberly Shoenbill, and Marc Bjurlin Hannah KayHannah Kay , Ram Sankar BasakRam Sankar Basak , Deborah UsingerDeborah Usinger , Ronald ChenRonald Chen , Richard MatulewiczRichard Matulewicz , Adam GoldsteinAdam Goldstein , Kimberly ShoenbillKimberly Shoenbill , and Marc BjurlinMarc Bjurlin View All Author Informationhttps://doi.org/10.1097/01.JU.0001008736.23117.7f.03AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Despite no established causal relationship between smoking and the development of prostate cancer (CaP), smoking may have negative impacts on health-related quality of life (HRQoL) among CaP survivors. Our study aims to evaluate the impact of smoking on HRQoL outcomes among survivors of CaP, and to characterize HRQoL outcomes based on intensity and duration of tobacco use. METHODS: We analyzed patients from the North Carolina Prostate Cancer Comparative Effectiveness & Survivorship Study (NC PROCESS). This population-based cohort study enrolled patients with newly-diagnosed localized CaP in collaboration with the NC Central Cancer Registry between January 1, 2011 & June 30, 2013 and longitudinally assessed HRQoL. The exposure variable, current smoking, was assessed at 3 months and every year following primary treatment. Linear and mixed-effects linear regression were used to analyze (standardized) HRQoL outcomes measured by the SF-12 instrument. RESULTS: A total of 842 patients responded to≥1 survey up to 60 months after diagnosis, and 499 completed the 60-month survey. 474 received prostatectomy (RALP) +/- radiation therapy (RT), 258 received RT without RALP, and 110 patients received brachytherapy (BT) without RALP or other RT. 544 patients smoked at some point during the survey collection period. Controlling for age, baseline outcome, treatment received, time since diagnosis, and subject-specific effects, concurrent smoking was associated with worse general health (GH) (mean difference (MD) = -1.12, p<0.05), mental health (MH) (MD = -1.28, p<0.05), physical function (PF) (MD = -1.58, p<0.01) but not with vitality (VT) (MD = -0.68, p=0.2) (Figure 1a-1d). CaP survivors who smoked for some or all of the survey period generally showed poorer outcomes at 5 years (Figure 1e-1h). For example, CaP survivors from each of the above smoking patterns and PF scores at 5 years, on average, about 7% points worse (p<0.01) compared to never smokers. CONCLUSIONS: There are baseline and long-term negative associations between smoking and worse HRQoL for survivors of CaP in the domains of GH, MH, and PF. These results underscore the need to treat smoking as an essential component of CaP care, with an emphasis on the longitudinal impacts of smoking on quality of life in CaP patients. Download PPT Source of Funding: Agency for Healthcare Research and Quality (AHRQ). Patient-Centered Outcomes Research Institute (PCORI) © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e619 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Hannah Kay More articles by this author Ram Sankar Basak More articles by this author Deborah Usinger More articles by this author Ronald Chen More articles by this author Richard Matulewicz More articles by this author Adam Goldstein More articles by this author Kimberly Shoenbill More articles by this author Marc Bjurlin More articles by this author Expand All Advertisement PDF downloadLoading ...