Mp74-07 Incidence of Sepsis Following Transrectal Prostate Biopsy Decreases to Zero With Betadine Preparation Per Rectum: A Single-Center Experience

You have accessJournal of UrologyProstate Cancer: Detection & Screening VI (MP74), Moderated Poster 741 May 2024MP74-07 INCIDENCE OF SEPSIS FOLLOWING TRANSRECTAL PROSTATE BIOPSY DECREASES TO ZERO WITH BETADINE PREPARATION PER RECTUM: A SINGLE-CENTER EXPERIENCE Jordan L. Mendelson, Megan Ngai, Mohammed Shah, Parth Joshi, Meredith Akerman, Anthony Corcoran, and Aaron Katz Jordan L. MendelsonJordan L. Mendelson , Megan NgaiMegan Ngai , Mohammed ShahMohammed Shah , Parth JoshiParth Joshi , Meredith AkermanMeredith Akerman , Anthony CorcoranAnthony Corcoran , and Aaron KatzAaron Katz View All Author Informationhttps://doi.org/10.1097/01.JU.0001008632.59099.b9.07AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Prostate cancer (PCa) is typically diagnosed with either a transrectal (TR) or transperineal (TP) biopsy. While each approach has its own risks and benefits, TR biopsies are associated with the greatest risk of infectious complications, including sepsis. This increased risk necessitates the use of both prophylactic antimicrobials and nonantibiotic strategies to reduce infectious complications following biopsy. One example of the latter is rectal preparation with a povidone-iodine (betadine) solution prior to biopsy. This study describes our experience with rectal betadine preparation in regards to post-biopsy complications, including fever/sepsis, in the 30 days following TR biopsies. METHODS: A retrospective review of a prospectively collected, IRB-approved database of patients who underwent prostate biopsy between January 2019 – September 2021 was performed. Complication rates within 30 days were collected for all patients who underwent TR biopsy and compared between those who received rectal betadine preparation prior to biopsy and those who did not. Patients who underwent TP biopsy were excluded from the study. RESULTS: Data was collected on 608 patients, who underwent a total of 629 total prostate biopsies. Of these, 278 patients underwent TR biopsy via either ultrasound guidance with MRI cognition (n=174) or MRI/ultrasound fusion (n=104). These patients were grouped based on whether they received rectal betadine preparation (n=55) or not (n=223). The two groups were similar in terms of age, race, highest PI-RADS score on MRI, prostate volume, and PSA level. The overall complication rate was lower among the betadine group (6.28% v. 1.82%, respectively), though this difference was not statistically significant. Similarly, the rate of infectious complications (i.e. fever/chills/sepsis) was lower among the betadine group (1.35% v. 0%), though this again was not statistically significant. Other complications included hematuria, hematochezia, perineal/urethral pain, urinary retention, urinary frequency, and hematospermia. CONCLUSIONS: Patients who received rectal betadine prior to TR biopsy had zero incidences of infectious complications. This was clinically significant, as infection is the most common cause of hospital readmission following TR biopsy and these admissions have been shown to be very expensive to the healthcare system. This data suggests that rectal betadine may be an effective nonantibiotic tool to decrease infectious complications. Further study is warranted in larger series. Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e1195 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Jordan L. Mendelson More articles by this author Megan Ngai More articles by this author Mohammed Shah More articles by this author Parth Joshi More articles by this author Meredith Akerman More articles by this author Anthony Corcoran More articles by this author Aaron Katz More articles by this author Expand All Advertisement PDF downloadLoading ...