Pd50-05 Patient-Level Data on Complications Following Prostate Biopsy: Results From the Probe-Pc Randomized Clinical Trial

You have accessJournal of UrologyProstate Cancer: Detection & Screening V (PD50)1 May 2024PD50-05 PATIENT-LEVEL DATA ON COMPLICATIONS FOLLOWING PROSTATE BIOPSY: RESULTS FROM THE PROBE-PC RANDOMIZED CLINICAL TRIAL Asef Aziz, Paul J. Feustel, Ronald P. Kaufman, Adrien Bernstein, Hugh A. G. Fisher, and Badar M. Mian Asef AzizAsef Aziz , Paul J. FeustelPaul J. Feustel , Ronald P. KaufmanRonald P. Kaufman , Adrien BernsteinAdrien Bernstein , Hugh A. G. FisherHugh A. G. Fisher , and Badar M. MianBadar M. Mian View All Author Informationhttps://doi.org/10.1097/01.JU.0001008620.35181.96.05AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: ProBE-PC was a randomized clinical trial designed to evaluate infectious and non-infectious complications following transrectal (TR-Bx) and transperineal (TP-Bx) prostate biopsy. While each outcome event can vary in severity, those are often grouped into a single category. Our aim was to provide patient-level data of each event within each category to provide clinically useful details. METHODS: Of the 718 completed procedures, 351 and 367 participants underwent TR-Bx and TP-Bx, respectively. Information on possible infectious (fever, urinary tract infection, fever, antibiotic use, health care utilization) and non-infectious (hematuria, urinary retention, health care utilization) was prospectively collected through direct contact at 2 weeks and at 30 days, including a review of the State-wide Health Information Exchange of New York (HIXNY), to identify all prescriptions, labs, microbiology, and clinic or hospital visits. RESULTS: There was no difference in complications between TR-Bx and TP-Bx groups. Overall, 19 patients (2.6%) had an infectious complication, and 14 patients (1.9%) had a non-infectious complication. Complications were either Clavien-Dindo Grade I (65.6%) or II (34.4%). There were 3 overnight hospitalizations due to infection, but there were no cases of sepsis. Of the 11 patients receiving antibiotic prescriptions after the biopsy, an indication could not be ascertained for 5 patients. While fever was reported by 12 patients, six reported it only during follow-up survey, without needing any intervention. Ten of the 17 patients' phone call to the office related to post-biopsy side effects only required reassurance. Minor hematuria was more frequent after TP-Bx (69.3% vs 79.3%, p<0.001), and hematochezia after TR-Bx (18.2% vs 8.0%, p<0.001), but no patients required an intervention. CONCLUSIONS: In our randomized study, both prostate biopsy procedures (TR-Bx and TP-Bx) were associated with a similar rate of minor, self-limited infectious and non-infectious complications. Source of Funding: Capital Region Medical Research Institute, SUNY-School of Public Health © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e1058 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Asef Aziz More articles by this author Paul J. Feustel More articles by this author Ronald P. Kaufman More articles by this author Adrien Bernstein More articles by this author Hugh A. G. Fisher More articles by this author Badar M. Mian More articles by this author Expand All Advertisement PDF downloadLoading ...