Key points are not available for this paper at this time.
Figure S1. Definition of intragenic rearrangements and the datasets and workflow used in this analysis (a) The datasets and workflow used in our analysis. The variant calling results were retrieved from the ICGC PCAWG cohort for the IGR calculation. Normalized gene expressions were used for the estimation of tumor infiltrating immune subsets and T-inflamed signatures. The results were validated in five clinical datasets. (b) Schematic showing the exon alterations resulting from intragenic rearrangements. (c) Scatter plot demonstrating that the number of missense variants correlate almost linearly with the number of all mutations (Pearson R=0.997, p
Zhang et al. (Mon,) studied this question.