Figure S1 from Intragenic Rearrangement Burden Associates with Immune Cell Infiltration and Response to Immune Checkpoint Blockade in Cancer

Figure S1. Definition of intragenic rearrangements and the datasets and workflow used in this analysis (a) The datasets and workflow used in our analysis. The variant calling results were retrieved from the ICGC PCAWG cohort for the IGR calculation. Normalized gene expressions were used for the estimation of tumor infiltrating immune subsets and T-inflamed signatures. The results were validated in five clinical datasets. (b) Schematic showing the exon alterations resulting from intragenic rearrangements. (c) Scatter plot demonstrating that the number of missense variants correlate almost linearly with the number of all mutations (Pearson R=0.997, p<2.2e-16). Values on axes are normalized by square root.