February 26, 2024The Lancet Diabetes & Endocrinology167 citationsOpen Access

5-year follow-up of the randomised Diabetes Remission Clinical Trial (DiRECT) of continued support for weight loss maintenance in the UK: an extension study

MLMichael EJ Lean WLW. S. Leslie ABAlison C. Barnes

Key Points

Participants in the intervention maintained significant weight loss, with 36% in remission from type 2 diabetes after 5 years.
At 5 years, 81% of those who lost over 10 kg were still in remission, indicating effectiveness of the weight management strategy.
The approach utilized continued low-intensity dietary support to sustain weight loss and enhance health outcomes over 5 years post-baseline assessment of the trial participants' progress. A diverse group of individuals benefited, suggesting the method's broad applicability in diabetes management.

Abstract

In DiRECT, a randomised controlled effectiveness trial, weight management intervention after 2 years resulted in mean weight loss of 7·6 kg, with 36% of participants in remission of type 2 diabetes. Of 36 in the intervention group who maintained over 10 kg weight loss at 2 years, 29 (81%) were in remission. Continued low-intensity dietary support was then offered up to 5 years from baseline to intervention participants, aiming to maintain weight loss and gain clinical benefits. This extension study was designed to provide observed outcomes at 5 years.

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