What question did this study set out to answer?

To investigate the significance of mismatch repair deficiency (dMMR) and microsatellite instability (MSI) in adrenocortical carcinoma (ACC).

February 9, 2026Open Access

Mismatch repair deficiency and microsatellite instability in adrenocortical carcinoma

Key Points

To investigate the significance of mismatch repair deficiency (dMMR) and microsatellite instability (MSI) in adrenocortical carcinoma (ACC).
Examined cases of adrenocortical carcinoma for dMMR and MSI status.
Evaluated the relationship between dMMR, MSI, and clinical features.
Analyzed the implications of dMMR for immunotherapy response and hereditary cancer risk.
dMMR is present in a minority of ACC cases, often without MSI.
Lynch syndrome accounts for some dMMR cases but is not predictive of clinical outcomes.
MMR testing is crucial for identifying hereditary cancer risk, regardless of MSI status.

Abstract

DMMR occurs in a minority of ACC, often without MSI. Although Lynch syndrome accounts for a subset of cases, dMMR is not predictive of clinical features or ICI response. Nonetheless, MMR testing remains important for identifying individuals at hereditary cancer risk.

Mismatch repair deficiency and microsatellite instability in adrenocortical carcinoma

Key Points

Abstract

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