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February 9, 2026ESMO Open4 citationsOpen Access

Mismatch repair deficiency and microsatellite instability in adrenocortical carcinoma

BAB. AltieriSKS. KircherSHS. Herterich

Key Points

  • To investigate the significance of mismatch repair deficiency (dMMR) and microsatellite instability (MSI) in adrenocortical carcinoma (ACC).
  • Examined cases of adrenocortical carcinoma for dMMR and MSI status.
  • Evaluated the relationship between dMMR, MSI, and clinical features.
  • Analyzed the implications of dMMR for immunotherapy response and hereditary cancer risk.
  • dMMR is present in a minority of ACC cases, often without MSI.
  • Lynch syndrome accounts for some dMMR cases but is not predictive of clinical outcomes.
  • MMR testing is crucial for identifying hereditary cancer risk, regardless of MSI status.

Abstract

DMMR occurs in a minority of ACC, often without MSI. Although Lynch syndrome accounts for a subset of cases, dMMR is not predictive of clinical features or ICI response. Nonetheless, MMR testing remains important for identifying individuals at hereditary cancer risk.

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Cite This Study

Altieri et al. (2026) studied this question.

synapsesocial.com/papers/69897983f0ec2af6756e730dhttps://doi.org/10.1016/j.esmoop.2025.106030
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