Hypercoagulability and vascular proinflammatory activation promote cardiac-cerebral fibrinogenesis in a rodent model of Chagas Disease

Key Points

• To investigate how hypercoagulability and vascular inflammation contribute to fibrin formation in Chagas disease.
• Used a rodent model of Chagas disease to evaluate cardiac and cerebral fibrinogenesis.
• Measured relevant markers of inflammation and coagulation at different stages of infection.
• Assessed the role of endothelial cells in fibrin formation.
• Confirmed increased fibrin deposition in cardiac and cerebral tissues during infection stages.
• Hypercoagulability and vascular inflammation significantly correlated with increased fibrinogenesis.
• Identified potential therapeutic targets related to vascular activation in Chagas disease.