Hypercoagulability and vascular proinflammatory activation promote cardiac-cerebral fibrinogenesis in a rodent model of Chagas Disease

Subhadip Choudhuri; Jain Garg Nisha

doi:10.1080/22221751.2026.2631204

February 11, 2026Emerging Microbes & InfectionsOpen Access

Hypercoagulability and vascular proinflammatory activation promote cardiac-cerebral fibrinogenesis in a rodent model of Chagas Disease

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Key Points

To investigate how hypercoagulability and vascular inflammation contribute to fibrin formation in Chagas disease.
Used a rodent model of Chagas disease to evaluate cardiac and cerebral fibrinogenesis.
Measured relevant markers of inflammation and coagulation at different stages of infection.
Assessed the role of endothelial cells in fibrin formation.
Confirmed increased fibrin deposition in cardiac and cerebral tissues during infection stages.
Hypercoagulability and vascular inflammation significantly correlated with increased fibrinogenesis.
Identified potential therapeutic targets related to vascular activation in Chagas disease.

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Implication

A rodent model demonstrates fibrinogenesis driven by hypercoagulability and proinflammatory activation in Chagas disease, suggesting new therapeutic targets.

Abstract

AT, IT, and CT: Acute, intermediate, and chronic stages of T. cruzi infection, respectively; APTT: Activated partial thromboplastin time; BCV: Bicistronic immunogen; BCVR: BCV adjuvanted with RIG-I agonist; CD: Chagas disease; EC: Endothelial cells; INR: International normalized ratio; LV: Left ventricle; PT: Prothrombin time; SMC: Smooth muscle cell; TF: Tissue factor; Tc: Trypanosoma cruzi; uPA: Urokinase plasminogen activator; VCAM1: Vascular Cell adhesion molecule 1; VEGF: Vascular endothelial growth factor.

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Cite This Study

Choudhuri et al. (2026) studied this question.

synapsesocial.com/papers/699010942ccff479cfe56f3f https://doi.org/10.1080/22221751.2026.2631204

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Hypercoagulability and vascular proinflammatory activation promote cardiac-cerebral fibrinogenesis in a rodent model of Chagas Disease

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Hypercoagulability and vascular proinflammatory activation promote cardiac-cerebral fibrinogenesis in a rodent model of Chagas Disease

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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