Key result
Preimmunization with an attenuated Trypanosoma cruzi strain significantly prevented the development of electrocardiographic alterations after challenge with a pathogenic strain (5.3% vs 63.6%, p=0.000095).
Why the study?
Does preimmunization with attenuated Trypanosoma cruzi prevent electrocardiographic alterations in a murine model of Chagas' disease?
Population
Murine model of Chagas' disease
Comparison
Preimmunization with 3 intraperitoneal inocula… vs Infection with pathogenic T. cruzi strain…
Design
Preclinical
Follow-up
293 days
Authors
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Hypothesis-generating for Chagas vaccination strategies; leaves open translation and safety in humans.
Does preimmunization with attenuated Trypanosoma cruzi prevent electrocardiographic alterations in a murine model of Chagas' disease?
Absolute Event Rate: 5.3% vs 63.6%
p-value: p=0.000095
Preimmunization with an attenuated T. cruzi strain significantly prevents electrocardiographic and histopathologic alterations in a murine model of Chagas' disease.
Cuneo et al. (1989) studied Chagas' disease (n=95). Preinoculation of an attenuated Trypanosoma cruzi strain (TCC) vs. Pathogenic T. cruzi strain (TS COB) infection without preimmunization was evaluated on Electrocardiographic alterations (supraventricular tachycardia, sinus bradycardia, and persisting first degree AV blocks) (p=0.000095). Preimmunization with an attenuated Trypanosoma cruzi strain significantly prevented the development of electrocardiographic alterations after challenge with a pathogenic strain (5.3% vs 63.6%, p=0.000095).
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