Key result
In a murine model of Chagas' disease, infection with the SGO-Z12 strain resulted in a significantly higher survival rate (77.1%) compared to the Tulahuen strain (50.0%; P<0.01).
Population
Murine model of experimental Chagas' disease
Comparison
Infection and re-infection with Trypanosoma… vs Non-infected mice, and comparison between…
Design
Preclinical
Authors
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Strain-specific survival in murine Chagas cautions against human extrapolation; leaves open strain effects on cardiopathy progression.
Absolute Event Rate: 77.1% vs 50%
p-value: p=<0.01
Different T. cruzi strains and re-infection events alter host-parasite equilibrium and contribute to the progression of Chagas cardiopathy in a murine model.
Bustamante et al. (2003) studied Chagas' disease. T. cruzi SGO-Z12 strain infection vs. T. cruzi Tulahuen strain infection was evaluated on Survival in the indeterminate phase (p=<0.01). In a murine model of Chagas' disease, infection with the SGO-Z12 strain resulted in a significantly higher survival rate (77.1%) compared to the Tulahuen strain (50.0%; P<0.01).
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