Key result
Different inbred mouse strains exhibited varying severities of myocarditis and cardiomyopathy following T. cruzi infection, suggesting background genes drive cardiac pathogenesis.
Population
Seven inbred mouse strains (DBA/1, DBA/2, BALB/c, B10.T (6R), B10.Q, B10.D2, and B6)
Design
Preclinical
Follow-up
100 days
Authors
Loading...
Host genetics may shape Chagas cardiomyopathy severity in mice; hypothesis-generating and requires human validation before any clinical consideration.
Different inbred mouse strains exhibit varying degrees of myocarditis and cardiomyopathy following T. cruzi infection, suggesting background genes drive cardiac pathogenesis in Chagas' disease.
Rowland et al. (1992) studied Chronic Chagas' cardiomyopathy / Trypanosoma cruzi infection. Inbred mouse strain genetics vs. Other inbred strains was evaluated on Severity of inflammation (myocarditis) and cardiomyopathy. Different inbred mouse strains exhibited varying severities of myocarditis and cardiomyopathy following T. cruzi infection, suggesting background genes drive cardiac pathogenesis.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: