Why the study?
Does chronic T. cruzi infection alter cardiopulmonary function and cardiac receptor density in C57BL/6 mice?
Population
C57BL/6 mice
Comparison
Intraperitoneal injection of 100 trypomastigote… vs Uninfected mice, matched in age
Design
Preclinical
Follow-up
8 months
Authors
Loading...
Provides a murine model for Chagas cardiomyopathy; leaves open translation to human disease and therapies.
Does chronic T. cruzi infection alter cardiopulmonary function and cardiac receptor density in C57BL/6 mice?
Chronic T. cruzi infection in a mouse model leads to cardiopulmonary dysfunction, myocardial fibrosis, and altered autonomic receptor densities, providing a preclinical model for Chagas cardiomyopathy.
Rocha et al. (2006) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: