Population
Swiss mice, chronically infected with Trypanosoma cruzi strains, spontaneously surviving after 154 to 468…
Design
Preclinical
Follow-up
154 to 468 days
Authors
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Suggests fibrosis reversibility in Chagas cardiomyopathy models; leaves open translation to human therapy.
The Swiss mouse model of chronic Trypanosoma cruzi infection demonstrates ultrastructural and immunochemical features of Chagas cardiomyopathy, including inflammation-associated fibrogenesis and potential reversibility.
Andrade et al. (1986) studied this question.
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