March 23, 2004Infection and ImmunityOpen Access

Pathology Affects Different Organs in Two Mouse Strains Chronically Infected by a Trypanosoma cruzi Clone: a Model for Genetic Studies of Chagas’ Disease

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Population

Six- to eight-week-old A/J, C3H/HePAS, BALB/c, DBA/2, C57BL/6, F1, and F2 mice

Comparison

Intraperitoneal infection with 10^6 Trypanosoma… vs Comparison between different inbred mouse…

Design

Preclinical, Slides examined in a blind fashion

Follow-up

up to 600 days postinfection

Authors

CMCláudio Romero Farias MarinhoUniversidade de São Paulo DBDaniella Zanetti BucciHospital Israelita Albert Einstein MDM.L. DagliUniversidade de São Paulo

Discussion

Member takes

Implication

Does not alter Chagas management; hypothesis-generating for host genetic determinants of cardiac tropism.

Structured PICO

Population

Six- to eight-week-old A/J, C3H/HePAS, BALB/c, DBA/2, C57BL/6, F1 (A/J x C3H/HePAS), and F2 (A/J x C3H/HePAS) mice

Intervention

Intraperitoneal infection with 10^6 Trypanosoma cruzi trypomastigotes of the Sylvio X10/4 clone

Comparator

Comparison between different inbred mouse strains (e.g., C3H/HePAS vs A/J) and noninfected controls

Outcome

Histopathological analysis of inflammatory infiltrates in the heart, liver, and striated muscle, and tissue parasitism at day 120 to 600 postinfectionsurrogate

Host genetic factors determine the organ-specific targeting of chronic inflammatory lesions in Trypanosoma cruzi infection, offering a novel murine model for studying Chagasic cardiomyopathy.

Cite This Study

Marinho et al. (2004) studied this question.

synapsesocial.com/papers/6a9ed2db01b90458ac61e7d8 https://doi.org/10.1128/iai.72.4.2350-2357.2004

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Pathology Affects Different Organs in Two Mouse Strains Chronically Infected by a Trypanosoma cruzi Clone: a Model for Genetic Studies of Chagas’ Disease

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Pathology Affects Different Organs in Two Mouse Strains Chronically Infected by a Trypanosoma cruzi Clone: a Model for Genetic Studies of Chagas’ Disease

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider