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September 12, 2025ParasitologiaOpen Access

Progression of Trypanosoma cruzi Dm28c Strain Infection in a BALB/c Mouse Experimental Model

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Experimental model reveals increased parasitemia and immune response in BALB/c mice infected with T. cruzi, suggesting disease characteristics.

Infected BALB/c mice exhibited a peak of parasitemia at 14 dpi, followed by a decline that reflects disease progression.
Spleen weight increased up to sixfold by 21 dpi compared to uninfected controls, correlating with the observed parasitemia levels.
Histological analysis indicated focal inflammatory infiltrates in the heart starting at 7 dpi, intensifying through 21 dpi.
Dynamic changes in inflammatory cytokines were detected during infection, implying a complex immune response to T. cruzi.

Hernandez et al. (2025) studied this question.

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Experimental model reveals increased parasitemia and immune response in BALB/c mice infected with T. cruzi, suggesting disease characteristics.