July 21, 2025Open Access

Progression of Trypanosoma cruzi Dm28c Strain Infection in a BALB/c Mouse Experimental Model

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Infection model shows parasitemia peaks and inflammatory cytokine dynamics in BALB/c mice, suggesting a model for Chagas disease.

The Dm28c strain of Trypanosoma cruzi causes distinct clinical outcomes in the BALB/c mouse model of Chagas disease.
Mice exhibit peak parasitemia at 14 days post-infection, showing a notable decrease afterward.
Inflammatory cytokines in the spleen show increased levels early in the infection, establishing key immune responses.
The model highlights Chagas disease progression, emphasizing its potential for understanding host-parasite interactions.

Hernandez et al. (2025) studied this question.

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