Key result
In a murine model, mice infected with the SGO-Z12 T. cruzi strain had a significantly higher survival rate (77.1%) compared to those infected with the Tulahuen strain (50.0%; P<0.01).
Population
Murine model of Chagas' disease
Comparison
Infection and re-infection with Trypanosoma… vs Non-infected mice, and comparison between…
Design
Preclinical
Authors
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T. cruzi strain variation may influence Chagas outcomes; leaves open parasite genetics as driver of indeterminate-phase cardiopathy.
Absolute Event Rate: 77.1% vs 50%
p-value: p=<0.01
Different Trypanosoma cruzi strains and re-infection events alter the host-parasite equilibrium and may drive the progression of cardiopathy during the clinically silent indeterminate phase of Chagas' disease.
Bustamante et al. (2003) studied Chagas' disease. Trypanosoma cruzi strains (SGO-Z12 vs Tulahuen) and re-infection vs. Tulahuen strain / single infection was evaluated on Survival in the indeterminate phase (p=<0.01). In a murine model, mice infected with the SGO-Z12 T. cruzi strain had a significantly higher survival rate (77.1%) compared to those infected with the Tulahuen strain (50.0%; P<0.01).
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