Why the study?
Does reinfection with Trypanosoma cruzi during the acute or chronic phase worsen electrocardiographic abnormalities in infected mice?
Population
Mice infected with Trypanosoma cruzi
Comparison
Reinfection with Trypanosoma cruzi during the… vs Infection with Trypanosoma cruzi without…
Design
Preclinical
Follow-up
Up to 90 days post-infection
Authors
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Acute reinfection worsens ECG outcomes in murine Chagas models; hypothesis-generating and leaves open translation to patients.
Does reinfection with Trypanosoma cruzi during the acute or chronic phase worsen electrocardiographic abnormalities in infected mice?
Reinfection with T. cruzi during the acute phase leads to more severe electrocardiographic alterations, such as AV blocks, compared to single infection or chronic phase reinfection in a mouse model.
Bustamante et al. (2004) studied this question.
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