Key result
Trypanosoma cruzi infection in mice altered cardiac mitochondrial structure, with 83% of Tulahuen-infected showing matrix increase and 91% of SGO Z12-infected showing diameter reduction (P<0.05).
Population
Mice in the chronic indeterminate stage (75 days post-infection) of Trypanosoma cruzi infection
Design
Preclinical
Follow-up
75 days post-infection
Authors
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Mitochondrial remodeling occurs in the indeterminate phase of murine Chagas disease; leaves open relevance to human progression and requires clinical validation.
p-value: p=<0.05
Cardiac mitochondria undergo significant structural and functional changes during the chronic indeterminate phase of Chagas' disease in mice, indicating this phase is not pathophysiologically silent.
Báez et al. (2012) studied Chagas' disease. Trypanosoma cruzi infection (Tulahuen and SGO Z12 strains) was evaluated on Cardiac mitochondrial structure and function (p=<0.05). Trypanosoma cruzi infection in mice altered cardiac mitochondrial structure, with 83% of Tulahuen-infected showing matrix increase and 91% of SGO Z12-infected showing diameter reduction (P<0.05).
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