June 14, 2019PLoS ONEOpen Access

Impaired frequencies and function of platelets and tissue remodeling in chronic Chagas disease

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Why the study?

Increased soluble P-selectin is linked to Chagas cardiomyopathy severity, prompting exploration of platelet and endothelial activation, tissue remodeling, and coagulation biomarkers across clinical stages.

Population

Patients at different clinical stages of chronic Chagas heart disease and uninfected subjects

Comparison

Patients with chronic Chagas disease vs uninfected subjects across disease severity

Authors

CPClaudia PengueHospital General de Agudos Dr. TEODORO ALVAREZ GCGonzalo Leandro CesarAcademia Nacional de Medicina GBGraciela BertocchiHospital General de Agudos Dr. TEODORO ALVAREZ

Discussion

Member takes

Implication

Suggests endothelial activation in Chagas cardiomyopathy; hypothesis-generating for platelet-endothelial markers in progression.

Structured PICO

Population

96 subjects, including 52 with chronic Chagas disease (stratified by Kuschnir grading G0-G3), 35 uninfected healthy controls, and 9 with noninfectious heart failure. Recruited at a single center in Argentina. Excluded patients with history of hypertension, vascular, ischemic or congenital heart disease, cancer, HIV, syphilis, diabetes, arthritis, allergy, and coagulation disorders.

Outcome

Expression of biomarkers of platelet and endothelial activation, tissue remodeling, and mediators of the coagulation cascade (including CD41a, CD62P, endothelin-1, procollagen I, fibrinogen, and von Willebrand factor)surrogate

Chronic T. cruzi infection induces hemostatic alterations, including impaired platelet activation and increased endothelial activation, even in asymptomatic patients.

Limitations

Assays were not run for all the samples due to sample availability

Cite This Study

Pengue et al. (2019) studied this question.

synapsesocial.com/papers/6a886db08e586ad1c8a558bf https://doi.org/10.1371/journal.pone.0218260

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Impaired frequencies and function of platelets and tissue remodeling in chronic Chagas disease

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Impaired frequencies and function of platelets and tissue remodeling in chronic Chagas disease

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider