Molecular engineering of ionic organic phototheranostic agents for NIR-II imaging-guided synergistic phototherapy

Key Points

• This research aims to engineer ionic small-molecule phototheranostics to optimize their imaging and therapeutic capabilities.
• Developed ionic phototheranostics with engineered positive charges
• Balanced hydrophilicity and hydrophobicity for improved functionality
• Evaluated the NIR-II emission and reactive oxygen species generation
• Achieved efficient NIR-II emission with the optimized agent, 2PyI
• Generated reactive oxygen species effectively during phototherapy
• Demonstrated potential for enhanced cancer treatment applications