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February 14, 2026Chemical Communications0 citations

Molecular engineering of ionic organic phototheranostic agents for NIR-II imaging-guided synergistic phototherapy

JGJianye GongQJQuan JinYZYue Zhang

Key Points

  • This research aims to engineer ionic small-molecule phototheranostics to optimize their imaging and therapeutic capabilities.
  • Developed ionic phototheranostics with engineered positive charges
  • Balanced hydrophilicity and hydrophobicity for improved functionality
  • Evaluated the NIR-II emission and reactive oxygen species generation
  • Achieved efficient NIR-II emission with the optimized agent, 2PyI
  • Generated reactive oxygen species effectively during phototherapy
  • Demonstrated potential for enhanced cancer treatment applications

Abstract

We develop ionic small-molecule phototheranostics by molecular engineering of positive charges and hydrophilicity/hydrophobicity balance. The optimized agent, 2PyI, achieves balanced amphiphilicity, enabling efficient NIR-II emission, reactive oxygen species generation, and...

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Cite This Study

Gong et al. (2026) studied this question.

synapsesocial.com/papers/699011602ccff479cfe58020https://doi.org/10.1039/d6cc00306k
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