What question did this study set out to answer?

To explore the potential of halogenated nucleosides as radiosensitizers through deep inner-shell photoionization.

February 19, 2026Physical Chemistry Chemical Physics1 citationsOpen Access

Dissociation of halogenated deoxyuridines as potential radiosensitizers, induced by deep inner-shell photoionization -- experiment and modeling.

KPKerttu-Inkeri PusaUniversity of Turku EKEdwin KukkUniversity of Turku MBMarta BerholtsUniversity of Tartu

Key Points

To explore the potential of halogenated nucleosides as radiosensitizers through deep inner-shell photoionization.
Conducted experiments using halogenated nucleosides in radiotherapy
Utilized modeling to study charge dynamics
Analyzed the effects of deep inner-shell ionization on molecular behavior
Halogenated nucleosides showed increased X-ray damage to tumor cells
Photoionization led to significant molecular and charge changes
Demonstrated potential enhancement of radiotherapy effectiveness by utilizing these compounds

Abstract

Halogenated nucleosides are known candidates for enhancing X-ray damage in radiotherapy of tumors and are also excellent model systems for investigating molecular and charge dynamics following deep inner-shell ionization. We...

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