Dissociation of halogenated deoxyuridines as potential radiosensitizers, induced by deep inner-shell photoionization -- experiment and modeling.

Kerttu-Inkeri Pusa; Edwin Kukk; Marta Berholts; Tatiana Marchenko; Iyas Ismail; D. Céolin; Marc Simon; Oksana Travnikova

doi:10.1039/d5cp04872a

January 1, 2026Physical Chemistry Chemical PhysicsOpen Access

Dissociation of halogenated deoxyuridines as potential radiosensitizers, induced by deep inner-shell photoionization -- experiment and modeling.

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Key Points

To explore the potential of halogenated nucleosides as radiosensitizers through deep inner-shell photoionization.
Conducted experiments using halogenated nucleosides in radiotherapy
Utilized modeling to study charge dynamics
Analyzed the effects of deep inner-shell ionization on molecular behavior
Halogenated nucleosides showed increased X-ray damage to tumor cells
Photoionization led to significant molecular and charge changes
Demonstrated potential enhancement of radiotherapy effectiveness by utilizing these compounds

Implication

This experiment investigates how halogenated nucleosides enhance X-ray damage in tumors, suggesting potential for better cancer treatments.

Abstract

Halogenated nucleosides are known candidates for enhancing X-ray damage in radiotherapy of tumors and are also excellent model systems for investigating molecular and charge dynamics following deep inner-shell ionization. We...

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Cite This Study

Pusa et al. (2026) studied this question.

synapsesocial.com/papers/6996a798ecb39a600b3ed759 https://doi.org/10.1039/d5cp04872a

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Dissociation of halogenated deoxyuridines as potential radiosensitizers, induced by deep inner-shell photoionization -- experiment and modeling.

Key Points

Implication

Abstract

Discussion

Cite This Study

Dissociation of halogenated deoxyuridines as potential radiosensitizers, induced by deep inner-shell photoionization -- experiment and modeling.

Key Points

Implication

Abstract

Discussion

Cite This Study

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