February 22, 2026

Metastatic renal cell carcinoma mimicking a thyroid neoplasm in a patient with concurrent papillary thyroid carcinoma: a case report

Key Points

To describe the case of a metastatic renal cell carcinoma mimicking a thyroid neoplasm in a patient with papillary thyroid carcinoma.
Case report detailing clinical presentation and pathologic findings.
Assessment of diagnostic challenges faced during the evaluation of thyroid nodules.
Examination of the histological characteristics of the tumours involved.
Identified clear cell renal cell carcinoma that resembled a thyroid neoplasm.
Confirmed concurrent diagnosis of multifocal papillary thyroid carcinoma.
Highlighted the complexities in differentiating between metastatic and primary thyroid tumours.

Abstract

Clear cell renal cell carcinoma (CCRCC) is a malignant tumour with a predilection for metastases. Metastasis to the thyroid is uncommon, and metastatic CCRCC can morphologically resemble primary thyroid tumours. We present a case of metastatic CCRCC to a thyroid follicular nodule on a background of concurrent multifocal papillary thyroid carcinoma (PTC) and discuss the diagnostic challenges this poses.

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