Kaempferol Alleviates Right Ventricular Hypertrophy in High Altitude Pulmonary Hypertension Rats by Modulating AMPK/ACC/CPT1B Axis and AMPK-mediated LDHA/PDHA1 Pathway

Key Points

• This research aims to evaluate kaempferol's effects on right ventricular structure and function in high-altitude pulmonary hypertension rats.
• Male Sprague-Dawley rats were utilized and subjected to high-altitude conditions.
• Kaempferol was administered to evaluate its impact on RV hypertrophy.
• AMPK/ACC and LDHA/PDHA1 pathways were analyzed to explore underlying mechanisms.
• Kaempferol treatment led to significant improvements in right ventricular structure and function.
• Modulation of the AMPK/ACC/CPT1B axis contributed to the observed effects.
• Enhanced activity of LDHA and PDHA1 pathways was noted, indicating metabolic shifts.