Kaempferol Alleviates Right Ventricular Hypertrophy in High Altitude Pulmonary Hypertension Rats by Modulating AMPK/ACC/CPT1B Axis and AMPK-mediated LDHA/PDHA1 Pathway

Qiongqiong Zhao; Shanshan SU; Chen Ju; Meiduo Huayu; Xingmei Nan; Xiaoping Li; Zhanqiang Li; D. Lu

doi:10.1039/d5fo04265h

January 1, 2026Food & Function

Kaempferol Alleviates Right Ventricular Hypertrophy in High Altitude Pulmonary Hypertension Rats by Modulating AMPK/ACC/CPT1B Axis and AMPK-mediated LDHA/PDHA1 Pathway

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Key Points

This research aims to evaluate kaempferol's effects on right ventricular structure and function in high-altitude pulmonary hypertension rats.
Male Sprague-Dawley rats were utilized and subjected to high-altitude conditions.
Kaempferol was administered to evaluate its impact on RV hypertrophy.
AMPK/ACC and LDHA/PDHA1 pathways were analyzed to explore underlying mechanisms.
Kaempferol treatment led to significant improvements in right ventricular structure and function.
Modulation of the AMPK/ACC/CPT1B axis contributed to the observed effects.
Enhanced activity of LDHA and PDHA1 pathways was noted, indicating metabolic shifts.

Implication

Animal study demonstrates kaempferol's potential to improve RV function in HAPH rats, suggesting therapeutic benefits.

Abstract

To evaluate the effect of Kaempferol on right ventricle (RV) structure/function in high-altitude pulmonary hypertension (HAPH) rats and to explore the underlying mechanisms. Methods: Male Sprague-Dawley rats (n=57) were exposed...

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Cite This Study

Zhao et al. (2026) studied this question.

synapsesocial.com/papers/699a9d27482488d673cd2da3 https://doi.org/10.1039/d5fo04265h

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Kaempferol Alleviates Right Ventricular Hypertrophy in High Altitude Pulmonary Hypertension Rats by Modulating AMPK/ACC/CPT1B Axis and AMPK-mediated LDHA/PDHA1 Pathway

Key Points

Implication

Abstract

Discussion

Cite This Study

Kaempferol Alleviates Right Ventricular Hypertrophy in High Altitude Pulmonary Hypertension Rats by Modulating AMPK/ACC/CPT1B Axis and AMPK-mediated LDHA/PDHA1 Pathway

Key Points

Implication

Abstract

Discussion

Cite This Study

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