The aim is to explore how different substrates affect the Symbol Digit Modalities Test (SDMT) impairment in multiple sclerosis patients based on the onset age.
Examined the clinical features of multiple sclerosis in two groups: adult-onset and late-onset patients.
Utilized MRI to assess brain network dysfunction in adult-onset patients and neurodegenerative processes in late-onset patients.
Analyzed data to determine correlations between SDMT scores and identified MRI findings.
Found that adult-onset patients primarily show network dysfunction associated with SDMT impairment.
Identified neurodegenerative processes as the main factor affecting SDMT scores in late-onset patients.
Demonstrated significant differences in SDMT impairment substrates between the two cohorts.
Abstract
Substrates contributing to SDMT impairment differ between these two distinct cohorts, being primarily driven by network dysfunction in AOMS and neurodegenerative processes in LOMS.