Clinical and MRI substrates of Symbol Digit Modalities Test impairment in multiple sclerosis patients with an adult- and late-onset

Q: What does this research mean for the field?

Network dysfunction primarily drives Symbol Digit Modalities Test impairment in adult-onset multiple sclerosis patients, while neurodegenerative processes are the main contributors in late-onset patients. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Antonia Wenger; Elisabetta Pagani; Alessandro Meani; Paolo Preziosa; Antonio Gallo; Elisabeth Solana; Menno M Schoonheim; Christian Enzinger; Felix Lüssi; Mario A Ocampo-Pineda; Alessandro Cagol; Matthias Weigel; Pasquale Calabrese; Ludwig Kappos; Cristina Granziera; Massimo Filippi; Maria A Rocca

doi:10.1177/13524585261417265

February 23, 2026Multiple Sclerosis JournalOpen Access

Clinical and MRI substrates of Symbol Digit Modalities Test impairment in multiple sclerosis patients with an adult- and late-onset

View Full Paper

Ask AI

Bookmark

Share

Key Points

The aim is to explore how different substrates affect the Symbol Digit Modalities Test (SDMT) impairment in multiple sclerosis patients based on the onset age.
Examined the clinical features of multiple sclerosis in two groups: adult-onset and late-onset patients.
Utilized MRI to assess brain network dysfunction in adult-onset patients and neurodegenerative processes in late-onset patients.
Analyzed data to determine correlations between SDMT scores and identified MRI findings.
Found that adult-onset patients primarily show network dysfunction associated with SDMT impairment.
Identified neurodegenerative processes as the main factor affecting SDMT scores in late-onset patients.
Demonstrated significant differences in SDMT impairment substrates between the two cohorts.

Implication

Analysis demonstrates different impairment substrates in multiple sclerosis patients with adult- and late-onset, suggesting tailored approaches are needed.

Abstract

Substrates contributing to SDMT impairment differ between these two distinct cohorts, being primarily driven by network dysfunction in AOMS and neurodegenerative processes in LOMS.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Wenger et al. (2026) studied this question.

synapsesocial.com/papers/699e91d7f5123be5ed04f92b https://doi.org/10.1177/13524585261417265

View Full Paper

Ask AI

Bookmark

Share

Clinical and MRI substrates of Symbol Digit Modalities Test impairment in multiple sclerosis patients with an adult- and late-onset

Key Points

Implication

Abstract

Discussion

Cite This Study

Clinical and MRI substrates of Symbol Digit Modalities Test impairment in multiple sclerosis patients with an adult- and late-onset

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

More related papers

More from Multiple Sclerosis Journal

Keep reading

More related papers

More from Multiple Sclerosis Journal