Event-related potentials and behavioural correlates of cognitive functions in MS: An EEG study during symbol digit modalities test

Our EEG-SDMT paradigm identified neurophysiological correlates of SDMT performance, which was significantly affected in pwMS. Although the P5 showed longer latencies in pwMS, this component did not differentiate between cognitively impaired and preserved individuals, likely because it is still too early to capture higher-order cognitive deficits. In contrast, RTs emerged as a more reliable and sensitive indicator of cognitive performance.