Regioselective Iridium(III)-Catalyzed C-H Cyclization Using Acetylene Surrogate: Direct Access to Hydroxylated Polycyclic Phthalazinones

Key Points

• This research aims to develop an efficient method for synthesizing tetracyclic phthalazinones via C-H cyclization.
• Utilized iridium(III) as a catalyst
• Implemented C-H cyclization with N-arylphthalazinones
• Used 2-chloroacetaldehyde as an alkyne equivalent
• Successfully synthesized a range of tetracyclic phthalazine derivatives
• Demonstrated broad substrate scope for various N-arylphthalazinones
• Achieved significant regioselectivity in product formation