Regioselective Iridium(III)-Catalyzed C-H Cyclization Using Acetylene Surrogate: Direct Access to Hydroxylated Polycyclic Phthalazinones

Hui Zhang; Lin Dong; Chao Zhang

doi:10.1039/d6ob00063k

January 1, 2025Organic & Biomolecular Chemistry

Regioselective Iridium(III)-Catalyzed C-H Cyclization Using Acetylene Surrogate: Direct Access to Hydroxylated Polycyclic Phthalazinones

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Key Points

This research aims to develop an efficient method for synthesizing tetracyclic phthalazinones via C-H cyclization.
Utilized iridium(III) as a catalyst
Implemented C-H cyclization with N-arylphthalazinones
Used 2-chloroacetaldehyde as an alkyne equivalent
Successfully synthesized a range of tetracyclic phthalazine derivatives
Demonstrated broad substrate scope for various N-arylphthalazinones
Achieved significant regioselectivity in product formation

Implication

An iridium(III)-catalyzed reaction creates tetracyclic phthalazine derivatives, suggesting new synthesis pathways.

Abstract

An iridium(III)-catalyzed C-H cyclization between N-arylphthalazinones and 2-chloroacetaldehyde has been developed. This reaction provides efficient access to tetracyclic phthalazine derivatives with broad substrate scope. 2-Chloroacetaldehyde serves as an alkyne equivalent,...

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Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/699fe3d995ddcd3a253e7e95 https://doi.org/10.1039/d6ob00063k

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Regioselective Iridium(III)-Catalyzed C-H Cyclization Using Acetylene Surrogate: Direct Access to Hydroxylated Polycyclic Phthalazinones

Key Points

Implication

Abstract

Discussion

Cite This Study

Regioselective Iridium(III)-Catalyzed C-H Cyclization Using Acetylene Surrogate: Direct Access to Hydroxylated Polycyclic Phthalazinones

Key Points

Implication

Abstract

Discussion

Cite This Study

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